Coronary risk factor profiles according to different age categories in premature coronary artery disease patients who have undergone percutaneous coronary intervention

Coronary risk factor profiles according to different age categories in premature coronary artery disease patients who have undergone percutaneous coronary intervention

  • Amini, M., Zayeri, F. & Salehi, M. Trend analysis of cardiovascular disease mortality, incidence, and mortality-to-incidence ratio: Results from global burden of disease study 2017. BMC Public Health 21(1), 401 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Ang, C. S. & Chan, K. M. A review of coronary artery disease research in Malaysia. Med. J. Malays. 71(Suppl 1), 42–57 (2016).

    CAS 

    Google Scholar 

  • National Heart Association of Malaysia (NHAM) and the Ministry of Health Malaysia. Annual Report of the NCVD-ACS Registry Year 2018–20192022. https://www.malaysianheart.org/?p=highlights&a=1796.

  • Lee, C. Y. et al. Sex and gender differences in presentation, treatment and outcomes in acute coronary syndrome, a 10 year study from a multi-ethnic Asian population: The Malaysian National Cardiovascular Disease Database-Acute Coronary Syndrome (NCVD-ACS) registry. PLoS ONE 16(2), e0246474 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Mandelzweig, L. et al. The second Euro Heart Survey on acute coronary syndromes: Characteristics, treatment, and outcome of patients with ACS in Europe and the Mediterranean Basin in 2004. Eur. Heart J. 27(19), 2285–2293 (2006).

    Article 
    PubMed 

    Google Scholar 

  • D’Agostino, R. B. Sr. et al. General cardiovascular risk profile for use in primary care: The Framingham Heart Study. Circulation 117(6), 743–753 (2008).

    Article 
    PubMed 

    Google Scholar 

  • McKay, A. J. et al. Universal screening at age 1–2 years as an adjunct to cascade testing for familial hypercholesterolaemia in the UK: A cost-utility analysis. Atherosclerosis 275, 434–443 (2018).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Ranthe, M. F. et al. A detailed family history of myocardial infarction and risk of myocardial infarction: A nationwide cohort study. PLoS ONE 10(5), e0125896 (2015).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Benjamin, E. J. et al. Heart disease and stroke statistics-2017 update: A report From the American Heart Association. Circulation 135(10), e146–e603 (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Poorzand, H. et al. Risk factors of premature coronary artery disease in Iran: A systematic review and meta-analysis. Eur. J. Clin. Invest. 49(7), e13124 (2019).

    Article 
    PubMed 

    Google Scholar 

  • Ohira, T. & Iso, H. Cardiovascular disease epidemiology in Asia: An overview. Circ. J. 77(7), 1646–1652 (2013).

    Article 
    PubMed 

    Google Scholar 

  • Department of Statistics Malaysia. Statistics on Causes of Death, Malaysia, 2021 (Department of Statistics Malaysia, 2022). https://www.dosm.gov.my/v1/index.php?r=column/cthemeByCat&cat=401&bul_id=R3VrRUhwSXZDN2k4SGN6akRhTStwQT09&menu_id=L0pheU43NWJwRWVSZklWdzQ4TlhUUT09#.

  • Muda, Z., Kadir, A. A., Yusof, Z. & Yaacob, L. H. Premature coronary artery disease among angiographically proven atherosclerotic coronary artery disease in North East of peninsular Malaysia. Int. J. Collab. Res. Intern. Med. Public Health 5(7), 507 (2013).

    Google Scholar 

  • Lee, C. Y. et al. Are there gender differences in coronary artery disease? The Malaysian National Cardiovascular Disease Database-Percutaneous Coronary Intervention (NCVD-PCI) Registry. PLoS ONE 8(8), e72382 (2013).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Shah, S. A. et al. Prevalence and risk factors of premature coronary artery disease: A comparative cross-sectional study between two time frames in Malaysia. Malays. J. Public Health Med. 15, 157–166 (2015).

    Google Scholar 

  • Zuhdi, A. S. et al. Young coronary artery disease in patients undergoing percutaneous coronary intervention. Ann. Saudi Med. 33(6), 572–578 (2013).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Aggarwal, A., Srivastava, S. & Velmurugan, M. Newer perspectives of coronary artery disease in young. World J. Cardiol. 8(12), 728–734 (2016).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Vikulova, D. N. et al. Premature atherosclerotic cardiovascular disease: Trends in incidence, risk factors, and sex-related differences, 2000 to 2016. J. Am. Heart Assoc. 8(14), e012178 (2019).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Nordestgaard, B. G. et al. Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: Guidance for clinicians to prevent coronary heart disease: Consensus statement of the European Atherosclerosis Society. Eur. Heart J. 34(45), 3478–3490 (2013).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Arnett, D. K., Khera, A. & Blumenthal, R. S. 2019 ACC/AHA Guideline on the Primary prevention of cardiovascular disease: Part 1, Lifestyle and Behavioral Factors. JAMA Cardiol. 4(10), 1043–1044 (2019).

    Article 
    PubMed 

    Google Scholar 

  • Toell, T. et al. Familial hypercholesterolaemia in patients with ischaemic stroke or transient ischaemic attack. Eur. J. Neurol. 25(2), 260–267 (2018).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Hosmer, D. W. & Lemesbow, S. Goodness of fit tests for the multiple logistic regression model. Commun. Stat.-Theory Methods 9(10), 1043–1069 (1980).

    Article 

    Google Scholar 

  • Breiman, L., Friedman, J. H., Olshen, R. A. & Stone, C. J. Classification and Regression Trees (Routledge, 2017).

    Book 

    Google Scholar 

  • Chawla, N. V., Bowyer, K. W., Hall, L. O. & Kegelmeyer, W. P. SMOTE: Synthetic minority over-sampling technique. J. Artif. Intell. Res. 16, 321–357 (2002).

    Article 

    Google Scholar 

  • Abderrahman, H. A., Al-Abdallat, I. M. & Idhair, A. K. Age threshold for proper definition of premature coronary artery disease in males. J. Forensic Leg. Med. 58, 45–49 (2018).

    Article 
    PubMed 

    Google Scholar 

  • Reibis, R. et al. Disparity in risk factor pattern in premature versus late-onset coronary artery disease: A survey of 15,381 patients. Vasc. Health Risk Manag. 8, 473–481 (2012).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Ahmad, W. A. W. et al. The journey of Malaysian NCVD—PCI (National Cardiovascular Disease Database—Percutaneous Coronary Intervention) Registry: A summary of three years report. Int. J. Cardiol. 165(1), 161–164 (2013).

    Article 
    PubMed 

    Google Scholar 

  • Aggarwal, A., Aggarwal, S., Sarkar, P. G. & Sharma, V. Predisposing factors to premature coronary artery disease in young (age </= 45 years) smokers: A single center retrospective case control study from India. J. Cardiovasc. Thorac. Res. 6(1), 15–19 (2014).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Kannel, W. B., Dawber, T. R., Friedman, G. D., Glennon, W. E. & McNamara, P. M. Risk factors in coronary heart disease. An evaluation of several serum lipids as predictors of coronary heart disease; the Framingham Study. Ann. Intern. Med. 61, 888–99 (1964).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Rubin, J. B. & Borden, W. B. Coronary heart disease in young adults. Curr. Atheroscler. Rep. 14(2), 140–149 (2012).

    Article 
    PubMed 

    Google Scholar 

  • Maroszynska-Dmoch, E. M. & Wozakowska-Kaplon, B. Clinical and angiographic characteristics of coronary artery disease in young adults: A single centre study. Kardiol. Pol. 74(4), 314–321 (2016).

    Article 
    PubMed 

    Google Scholar 

  • Bajaj, S. et al. Acute ST-segment elevation myocardial infarction in young adults: Who is at risk?. Coron. Artery Dis. 22(4), 238–244 (2011).

    Article 
    PubMed 

    Google Scholar 

  • Chacko, M., Sarma, P. S., Harikrishnan, S., Zachariah, G. & Jeemon, P. Family history of cardiovascular disease and risk of premature coronary heart disease: A matched case-control study. Wellcome Open Res. 5, 70 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Bachmann, J. M., Willis, B. L., Ayers, C. R., Khera, A. & Berry, J. D. Association between family history and coronary heart disease death across long-term follow-up in men: The Cooper Center Longitudinal Study. Circulation 125(25), 3092–3098 (2012).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Valdez, R., Yoon, P. W., Qureshi, N., Green, R. F. & Khoury, M. J. Family history in public health practice: A genomic tool for disease prevention and health promotion. Annu. Rev. Public Health 31, 69–87 (2010).

    Article 
    PubMed 

    Google Scholar 

  • Allport, S. A., Kikah, N., Abu Saif, N., Ekokobe, F. & Atem, F. D. Parental age of onset of cardiovascular disease as a predictor for offspring age of onset of cardiovascular disease. PLoS ONE 11(12), e0163334 (2016).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Filoche, S. et al. How is family health history discussed in routine primary healthcare? A qualitative study of archived family doctor consultations. BMJ Open 11(10), e049058 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Conway-Pearson, L. S. et al. Family health history reporting is sensitive to small changes in wording. Genet. Med. 18(12), 1308–1311 (2016).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Leander, K., Hallqvist, J., Reuterwall, C., Ahlbom, A. & de Faire, U. Family history of coronary heart disease, a strong risk factor for myocardial infarction interacting with other cardiovascular risk factors: Results from the Stockholm Heart Epidemiology Program (SHEEP). Epidemiology 12(2), 215–221 (2001).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Nasir, K. et al. Coronary artery calcification and family history of premature coronary heart disease: Sibling history is more strongly associated than parental history. Circulation 110(15), 2150–2156 (2004).

    Article 
    PubMed 

    Google Scholar 

  • Prabhakaran, D. & Jeemon, P. Should your family history of coronary heart disease scare you?. Mt. Sinai J. Med. 79(6), 721–732 (2012).

    Article 
    PubMed 

    Google Scholar 

  • Sesso, H. D. et al. Maternal and paternal history of myocardial infarction and risk of cardiovascular disease in men and women. Circulation 104(4), 393–398 (2001).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Kolber, M. R. & Scrimshaw, C. Family history of cardiovascular disease. Can. Fam. Physician 60(11), 1016 (2014).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Wu, C. Y. et al. High blood pressure and all-cause and cardiovascular disease mortalities in community-dwelling older adults. Medicine (Baltimore) 94(47), e2160 (2015).

    Article 
    PubMed 

    Google Scholar 

  • Christofaro, D. G. D., Casonatto, J., Vanderlei, L. C. M., Cucato, G. G. & Dias, R. M. R. Relationship between resting heart rate, blood pressure and pulse pressure in adolescents. Arq. Bras. Cardiol. 108(5), 405–410 (2017).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Oparil, S. et al. Hypertension. Nat. Rev. Dis. Primers 4, 18014 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Fernandes, R. A. et al. Resting heart rate is associated with blood pressure in male children and adolescents. J. Pediatr. 158(4), 634–637 (2011).

    Article 
    PubMed 

    Google Scholar 

  • Ettehad, D. et al. Blood pressure lowering for prevention of cardiovascular disease and death: A systematic review and meta-analysis. Lancet 387(10022), 957–967 (2016).

    Article 
    PubMed 

    Google Scholar 

  • World Health Organization. Hypertension. (2021).

  • Cai, Q., Mukku, V. K. & Ahmad, M. Coronary artery disease in patients with chronic kidney disease: A clinical update. Curr. Cardiol. Rev. 9(4), 331–339 (2013).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Mach, F. et al. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: Lipid modification to reduce cardiovascular risk: The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS). Eur. Heart J. 41(1), 111–188 (2020).

    Article 
    PubMed 

    Google Scholar 

  • Clinical Practice Guidelines of Stable Coronary Artery Disease. Clinical Practice Guidelines of Stable Coronary Artery Disease 2018 2nd edn. (National Heart Association of Malaysia, 2018).

    Google Scholar 

  • Clinical Practice Guidelines on Management of Dyslipidaemia. Clinical Practice Guidelines on Management of Dyslipidaemia 5th Edition: Ministry of Health. (2017).

  • Sadeghi, R., Adnani, N., Erfanifar, A., Gachkar, L. & Maghsoomi, Z. Premature coronary heart disease and traditional risk factors-can we do better?. Int. Cardiovasc. Res. J. 7(2), 46–50 (2013).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Hosseini, K. et al. Prevalence and trends of coronary artery disease risk factors and their effect on age of diagnosis in patients with established coronary artery disease: Tehran Heart Center (2005–2015). BMC Cardiovasc. Disord. 21(1), 477 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Obaya, M., Yehia, M., Hamed, L. & Fattah, A. A. Comparative study between elderly and younger patients with acute coronary syndrome. Egyp. J. Crit. Care Med. 3(2–3), 69–75 (2015).

    Article 

    Google Scholar 

  • Matsis, K. et al. Differing clinical characteristics between young and older patients presenting with myocardial infarction. Heart Lung Circ. 26(6), 566–571 (2017).

    Article 
    PubMed 

    Google Scholar 

  • Morovatdar, N. et al. Risk factor patterns for premature versus late-onset coronary artery disease in Iran: A systematic review and meta-analysis. Open Cardiovasc. Med. J. 13(1), 5–12 (2019).

    Article 

    Google Scholar 

  • Benfante, R. J., Reed, D. M., MacLean, C. J. & Yano, K. Risk factors in middle age that predict early and late onset of coronary heart disease. J. Clin. Epidemiol. 42(2), 95–104 (1989).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Tate, R. B., Manfreda, J. & Cuddy, T. E. The effect of age on risk factors for ischemic heart disease: The Manitoba Follow-Up Study, 1948–1993. Ann. Epidemiol. 8(7), 415–421 (1998).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Sengul, C. et al. Comparison of psychosocial risk factors between patients who experience acute myocardial infarction before and after 40 years of age. Turk. Kardiyol. Dern. Ars. 39(5), 396–402 (2011).

    Article 
    PubMed 

    Google Scholar 

  • Milane, A. et al. Association of hypertension with coronary artery disease onset in the Lebanese population. Springerplus 3, 533 (2014).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Muli, S. et al. Prevalence, awareness, treatment, and control of hypertension in older people: Results from the population-based KORA-age 1 study. BMC Public Health. 20(1), 1049 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Benetos, A., Petrovic, M. & Strandberg, T. Hypertension management in older and frail older patients. Circ. Res. 124(7), 1045–1060 (2019).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Pinto, E. Blood pressure and ageing. Postgrad. Med. J. 83(976), 109–114 (2007).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Oliveros, E. et al. Hypertension in older adults: Assessment, management, and challenges. Clin. Cardiol. 43(2), 99–107 (2020).

    Article 
    PubMed 

    Google Scholar 

  • Lionakis, N., Mendrinos, D., Sanidas, E., Favatas, G. & Georgopoulou, M. Hypertension in the elderly. World J. Cardiol. 4(5), 135–147 (2012).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Bellary, S., Kyrou, I., Brown, J. E. & Bailey, C. J. Type 2 diabetes mellitus in older adults: Clinical considerations and management. Nat. Rev. Endocrinol. 17(9), 534–548 (2021).

    Article 
    PubMed 

    Google Scholar 

  • Longo, M. et al. Diabetes and aging: From treatment goals to pharmacologic therapy. Front. Endocrinol. (Lausanne) 10, 45 (2019).

    Article 
    PubMed 

    Google Scholar 

  • Tchkonia, T. & Kirkland, J. L. Aging, cell senescence, and chronic disease: Emerging therapeutic strategies. JAMA 320(13), 1319–1320 (2018).

    Article 
    PubMed 

    Google Scholar 

  • Aggarwal, N. R. et al. Sex differences in ischemic heart disease: Advances, obstacles, and next steps. Circ. Cardiovasc. Qual. Outcomes 11(2), e004437 (2018).

    Article 
    PubMed 

    Google Scholar 

  • Prabakaran, S., Schwartz, A. & Lundberg, G. Cardiovascular risk in menopausal women and our evolving understanding of menopausal hormone therapy: Risks, benefits, and current guidelines for use. Ther. Adv. Endocrinol. Metab. 12, 20420188211013916 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Pahwa, M. B., Seth, S. & Seth, R. K. Lipid profile in various phases of menstrual cycle and its relationship with percentage plasma volume changes. Clin. Chim. Acta 273(2), 201–207 (1998).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Wu, T. T., Gao, Y., Zheng, Y. Y., Ma, Y. T. & Xie, X. Atherogenic index of plasma (AIP): A novel predictive indicator for the coronary artery disease in postmenopausal women. Lipids Health Dis. 17(1), 197 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Jousilahti, P., Vartiainen, E., Tuomilehto, J. & Puska, P. Sex, age, cardiovascular risk factors, and coronary heart disease: A prospective follow-up study of 14 786 middle-aged men and women in Finland. Circulation 99(9), 1165–1172 (1999).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Mumford, S. L., Dasharathy, S., Pollack, A. Z. & Schisterman, E. F. Variations in lipid levels according to menstrual cycle phase: Clinical implications. Clin. Lipidol. 6(2), 225–234 (2011).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • de Winther, M. P., Kanters, E., Kraal, G. & Hofker, M. H. Nuclear factor kappaB signaling in atherogenesis. Arterioscler. Thromb. Vasc. Biol. 25(5), 904–914 (2005).

    Article 
    PubMed 

    Google Scholar 

  • Boren, J. et al. Low-density lipoproteins cause atherosclerotic cardiovascular disease: Pathophysiological, genetic, and therapeutic insights: A consensus statement from the European Atherosclerosis Society Consensus Panel. Eur. Heart J. 41(24), 2313–2330 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Jeong, S. M. et al. Effect of change in total cholesterol levels on cardiovascular disease among young adults. J. Am. Heart Assoc. 7(12), e008819 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Yandrapalli, S., Nabors, C., Goyal, A., Aronow, W. S. & Frishman, W. H. Modifiable risk factors in young adults with first myocardial infarction. J. Am. Coll. Cardiol. 73(5), 573–584 (2019).

    Article 
    PubMed 

    Google Scholar 

  • Kaneko, H. et al. Lipid profile and subsequent cardiovascular disease among young adults aged < 50 years. Am. J. Cardiol. 142, 59–65 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Gencer, B. et al. Efficacy and safety of lowering LDL cholesterol in older patients: A systematic review and meta-analysis of randomised controlled trials. Lancet 396(10263), 1637–1643 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Mc Auley, M. T. & Mooney, K. M. LDL-C levels in older people: Cholesterol homeostasis and the free radical theory of ageing converge. Med. Hypotheses 104, 15–19 (2017).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Martin, S. S. et al. Friedewald-estimated versus directly measured low-density lipoprotein cholesterol and treatment implications. J. Am. Coll. Cardiol. 62(8), 732–739 (2013).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Miller, W. G. et al. Seven direct methods for measuring HDL and LDL cholesterol compared with ultracentrifugation reference measurement procedures. Clin. Chem. 56(6), 977–986 (2010).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Aggarwal, D. J., Kathariya, M. G. & Verma, D. P. K. LDL-C, NON-HDL-C and APO-B for cardiovascular risk assessment: Looking for the ideal marker. Indian Heart J. 73(5), 544–548 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Ferraro, R. A. et al. Contemporary management of dyslipidemia. Drugs 82(5), 559–576 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Kessler, T. & Schunkert, H. Coronary artery disease genetics enlightened by genome-wide association studies. JACC Basic. Transl. Sci. 6(7), 610–623 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Lorca, R. et al. Familial hypercholesterolemia in premature acute coronary syndrome. Insights from CholeSTEMI Registry. J. Clin. Med. 9(11), 3489 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Kramer, A. I., Trinder, M. & Brunham, L. R. Estimating the prevalence of familial hypercholesterolemia in acute coronary syndrome: A systematic review and meta-analysis. Can. J. Cardiol. 35(10), 1322–1331 (2019).

    Article 
    PubMed 

    Google Scholar 

  • Sheikh, M. et al. Association of serum gamma-glutamyltransferase and premature coronary artery disease. Neth. Heart J. 25(7–8), 439–445 (2017).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Kronenberg, F. Prediction of cardiovascular risk by Lp(a) concentrations or genetic variants within the LPA gene region. Clin. Res. Cardiol. Suppl. 14(Suppl 1), 5–12 (2019).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Lee, S. R. et al. LPA gene, ethnicity, and cardiovascular events. Circulation 135(3), 251–263 (2017).

    Article 
    CAS 
    PubMed 

    Google Scholar 

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